Advances in architectures, networks, systems and middleware technologies are leading to new concepts and platforms for computing, ranging from Clusters and Grids to Clouds and Datacenters, and result in an outstanding impact to numerous aspects of the modern world. The 19th Annual IEEE/ACM International Symposium in Cluster, Cloud, and Grid Computing (CCGrid 2019) is a forum bringing together international researchers, developers, and practitioners to present leading research activities and results on a broad range of topics related to these concepts, platforms, and their applications. The conference features keynotes, technical presentations, workshops, and posters, as well as the Doctoral Symposium and the SCALE challenge featuring live demonstrations. CCGrid has travelled over the world. Its next stop is in beautiful Larnaca, Cyprus, in May 2019.